PK3CB抗体应用：WB 1:500-2000 ELISA 1:5000-20000phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta(PIK3CB) Homo sapiens This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],

PKD1抗体应用：IHC-p 1:50-300polycystin 1, transient receptor potential channel interacting(PKD1) Homo sapiens This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on c

PKHA1抗体应用：WB 1:500-2000 ELISA 1:5000-20000pleckstrin homology domain containing A1(PLEKHA1) Homo sapiens This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010],

PKHG1抗体应用：WB 1:500-2000 ELISA 1:5000-20000PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,

PKHO2抗体应用：WB 1:500-2000

PKN1抗体应用：WB 1:500-2000 ELISA 1:5000-20000protein kinase N1(PKN1) Homo sapiens The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],

PKN3抗体应用：WB 1:500-2000 ELISA 1:5000-20000catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain does not bind the diacylglycerol (DAG).,enzyme regulation:Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation.,function:Contributes to invasiveness in malignant prostate cancer.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 REM (Hr1) repeats.,subcellular location:Nuclear and perinuclear Golgi region.,tissue specificity:Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.,

PKNX1抗体应用：WB 1:500-2000 ELISA 1:5000-20000similarity:Belongs to the TALE/MEIS homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow.,

PKP3抗体应用：WB 1:500-2000 ELISA 1:5000-20000plakophilin 3(PKP3) Homo sapiens This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014],

PKR2抗体应用：WB 1:500-2000 ELISA 1:5000-20000prokineticin receptor 2(PROKR2) Homo sapiens Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008],