pVHL (ABT-PVHL) mouse Monoclonal Antibody

pVHL (ABT-PVHL)  mouse monoclonal  antibody

应用：IHC-p 1:100-500 

产品名（Product Name）

pVHL (ABT-PVHL) mouse Monoclonal Antibody

货号（Catalog No.）

KL-16091

种类（Category）

Primary antibodies

宿主（Host）

Mouse/IgG2b, Kappa

反应种属（Species specificity）

Human

应用实验（Tested applications）

IHC-p

克隆性（Clonality）

Monoclonal

偶连物（Conjugation）

Unconjugated

免疫原（Immunogen）

Synthesized peptide derived from human pVHL

状态（Form）

Liquid

储存溶液（Buffer）

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

存放条件（Storage）

-20°C/1 year

纯化方式（Purity）

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

产品背景：von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008], 

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！