前蛋白转化酶枯草溶菌素9(PCSK9)重组蛋白

前蛋白转化酶枯草溶菌素9(PCSK9)重组蛋白

Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

FH3; HCHOLA3; NARC1; Hypercholesterolemia,Autosomal Dominant 3; Neural apoptosis-regulated convertase 1; Proprotein convertase 9; Subtilisin/kexin-like protease PC9

[ PROPERTIES ]

Residues: Ser156~Gln694

Tags: Two N-terminal Tags, His-tag and GST-tag

Accession: Q80W65

Host: E. coli

Subcellular Location: Cytoplasm. Secreted.

Endosome. Lysosome. Cell surface.

Purity: >90%

Endotoxin Level: <1.0EU per 1μg

(determined by the LAL method).

Formulation: Supplied as lyophilized form in PBS,

pH7.4, containing 5% trehalose, 0.01% sarcosyl.

Predicted isoelectric point: 7.5

Predicted Molecular Mass: 87.3kDa

Applications: SDS-PAGE; WB; ELISA; IP.

(May be suitable for use in other assays to be determined by the end user.)

[ USAGE ]

Reconstitute in sterile PBS, pH7.2-pH7.4.

[ STORAGE AND STABILITY ]

Storage: Avoid repeated freeze/thaw cycles.

Store at 2-8oC for one month.

Aliquot and store at -80oC for 12 months.

Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37oC for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

[ SEQUENCES ]

The sequence of the target protein is listed below.

SIPWN LERIIPAWHQ TEEDRSPDGS SQVEVYLLDT SIQGAHREIE GRVTITDFNSVPEEDGTRFH RQASKCDSHG THLAGVVSGR DAGVAKGTSL HSLRVLNCQG KGTVSGTLIGLEFIRKSQLI QPSGPLVVLL PLAGGYSRIL NAACRHLART GVVLVAAAGN FRDDACLYSPASAPEVITVG ATNAQDQPVT LGTLGTNFGR CVDLFAPGKD IIGASSDCST CFMSQSGTSQAAAHVAGIVA RMLSREPTLT LAELRQRLIH FSTKDVINMA WFPEDQQVLT PNLVATLPPSTHETGGQLLC RTVWSAHSGP TRTATATARC APEEELLSCS SFSRSGRRRG DWIEAIGGQQVCKALNAFGG EGVYAVARCC LVPRANCSIH NTPAARAGLE THVHCHQKDH VLTGCSFHWEVEDLSVRRQP ALRSRRQPGQ CVGHQAASVY ASCCHAPGLE CKIKEHGISG PSEQVTVACEAGWTLTGCNV LPGASLTLGA YSVDNLCVAR VHDTARADRT SGEATVAAAI CCRSRPSAKASWVQ

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